1,916 research outputs found
Testing fluvial erosion models using the transient response of bedrock rivers to tectonic forcing in the Apennines, Italy
The transient response of bedrock rivers to a drop in base level can be used to
discriminate between competing fluvial erosion models. However, some recent studies of
bedrock erosion conclude that transient river long profiles can be approximately
characterized by a transport‐limited erosion model, while other authors suggest that a
detachment‐limited model best explains their field data. The difference is thought to be
due to the relative volume of sediment being fluxed through the fluvial system. Using a
pragmatic approach, we address this debate by testing the ability of end‐member fluvial
erosion models to reproduce the well‐documented evolution of three catchments in the
central Apennines (Italy) which have been perturbed to various extents by an
independently constrained increase in relative uplift rate. The transport‐limited model is
unable to account for the catchments’response to the increase in uplift rate, consistent with
the observed low rates of sediment supply to the channels. Instead, a detachment‐limited
model with a threshold corresponding to the field‐derived median grain size of the
sediment plus a slope‐dependent channel width satisfactorily reproduces the overall
convex long profiles along the studied rivers. Importantly, we find that the prefactor in the
hydraulic scaling relationship is uplift dependent, leading to landscapes responding faster
the higher the uplift rate, consistent with field observations. We conclude that a slope‐
dependent channel width and an entrainment/erosion threshold are necessary ingredients
when modeling landscape evolution or mapping the distribution of fluvial erosion rates in
areas where the rate of sediment supply to channels is low
Influence of Sex/Gender and Race on Responses to Raltegravir Combined With Tenofovir-Emtricitabine in Treatment-Naive Human Immunodeficiency Virus-1 Infected Patients: Pooled Analyses of the STARTMRK and QDMRK Studies.
BACKGROUND: Antiretroviral therapy in human immunodeficiency virus (HIV)-infected women and blacks merits particular scrutiny because these groups have been underrepresented in clinical trials.
METHODS: To document the effects of raltegravir across sex and racial lines, we conducted a pooled subgroup analysis of the efficacy and safety of raltegravir 400 mg BID plus tenofovir-emtricitabine by sex (women vs men) and self-identified race (black vs non-black) using phase 3 studies in treatment-naive patients.
RESULTS: Study participants included 42 black women, 102 non-black women, 48 black men, and 477 non-black men. Clade B infections were less common in women (43.8%) than men (84.6%) and in blacks (45.6%) than non-blacks (80.5%). Baseline CD4 counts were ≤200 cells/µL in 52.2% of blacks and 31.6% of non-blacks. Black men had the largest proportion of patients with baseline CD4 counts/µL and the highest nontreatment-related discontinuation rate among the 4 sex-by-race subgroups. Human immunodeficiency virus-ribonucleic acid levels/mL were achieved at week 48 in 92.7% (95% confidence interval [CI], 80.1-98.5) of black women, 93.6% (95% CI, 86.6-97.6) of non-black women, 82.9% (95% CI, 67.9-92.8) of black men, and 91.4% (95% CI, 88.4-93.8) of non-black men. Serious clinical adverse events were reported in 9.0% of women versus 8.8% of men and in 11.1% of blacks versus 8.5% of non-blacks.
CONCLUSIONS: In this post hoc analysis of patients with previously untreated HIV-1 infection receiving raltegravir plus tenofovir-emtricitabine, generally comparable results were achieved across sex and racial subgroups. However, black men had a lower response rate than either black women or non-black men, partially attributable to lower baseline CD4 counts and higher discontinuation rates
Intermediate Tail Dependence: A Review and Some New Results
The concept of intermediate tail dependence is useful if one wants to
quantify the degree of positive dependence in the tails when there is no strong
evidence of presence of the usual tail dependence. We first review existing
studies on intermediate tail dependence, and then we report new results to
supplement the review. Intermediate tail dependence for elliptical, extreme
value and Archimedean copulas are reviewed and further studied, respectively.
For Archimedean copulas, we not only consider the frailty model but also the
recently studied scale mixture model; for the latter, conditions leading to
upper intermediate tail dependence are presented, and it provides a useful way
to simulate copulas with desirable intermediate tail dependence structures.Comment: 25 pages, 1 figur
Important Historical Efforts at Emergency Department Categorization in the United States and Implications for Regionalization
This article is drawn from a report created for the American College of Emergency Physicians (ACEP) Emergency Department (ED) Categorization Task Force and also reflects the proceedings of a breakout session, “Beyond ED Categorization—Matching Networks to Patient Needs,” at the 2010 Academic Emergency Medicine consensus conference, “Beyond Regionalization: Integrated Networks of Emergency Care.” The authors describe a brief history of the significant national and state efforts at categorization and suggest reasons why many of these efforts failed to persevere or gain wider implementation. The history of efforts to categorize hospital (and ED) emergency services demonstrates recognition of the potential benefits of categorization, but reflects repeated failures to implement full categorization systems or limited excursions into categorization through licensing of EDs or designation of receiving and referral facilities. An understanding of the history of hospital and ED categorization could better inform current efforts to develop categorization schemes and processes.ACADEMIC EMERGENCY MEDICINE 2010; 17:e154–e160 © 2010 by the Society for Academic Emergency MedicinePeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/79214/1/j.1553-2712.2010.00931.x.pd
Consistent thermodynamics for spin echoes
Spin-echo experiments are often said to constitute an instant of
anti-thermodynamic behavior in a concrete physical system that violates the
second law of thermodynamics. We argue that a proper thermodynamic treatment of
the effect should take into account the correlations between the spin and
translational degrees of freedom of the molecules. To this end, we construct an
entropy functional using Boltzmann macrostates that incorporates both spin and
translational degrees of freedom. With this definition there is nothing special
in the thermodynamics of spin echoes: dephasing corresponds to Hamiltonian
evolution and leaves the entropy unchanged; dissipation increases the entropy.
In particular, there is no phase of entropy decrease in the echo. We also
discuss the definition of macrostates from the underlying quantum theory and we
show that the decay of net magnetization provides a faithful measure of entropy
change.Comment: 15 pages, 2 figs. Changed figures, version to appear in PR
Vibrotactile pedals : provision of haptic feedback to support economical driving
The use of haptic feedback is currently an underused modality in the driving environment, especially with respect to vehicle manufacturers. This exploratory study evaluates the effects of a vibrotactile (or haptic) accelerator pedal on car driving performance and perceived workload using a driving simulator. A stimulus was triggered when the driver exceeded a 50% throttle threshold, past which is deemed excessive for economical driving. Results showed significant decreases in mean acceleration values, and maximum and excess throttle use when the haptic pedal was active as compared to a baseline condition. As well as the positive changes to driver behaviour, subjective workload decreased when driving with the haptic pedal as compared to when drivers were simply asked to drive economically. The literature suggests that the haptic processing channel offers a largely untapped resource in the driving environment, and could provide information without overloading the other attentional resource pools used in driving
Basins of attraction on random topography
We investigate the consequences of fluid flowing on a continuous surface upon
the geometric and statistical distribution of the flow. We find that the
ability of a surface to collect water by its mere geometrical shape is
proportional to the curvature of the contour line divided by the local slope.
Consequently, rivers tend to lie in locations of high curvature and flat
slopes. Gaussian surfaces are introduced as a model of random topography. For
Gaussian surfaces the relation between convergence and slope is obtained
analytically. The convergence of flow lines correlates positively with drainage
area, so that lower slopes are associated with larger basins. As a consequence,
we explain the observed relation between the local slope of a landscape and the
area of the drainage basin geometrically. To some extent, the slope-area
relation comes about not because of fluvial erosion of the landscape, but
because of the way rivers choose their path. Our results are supported by
numerically generated surfaces as well as by real landscapes
A Role for Noncoding Variation in Schizophrenia
A large portion of common variant loci associated with genetic risk for schizophrenia reside within noncoding sequence of unknown function. Here, we demonstrate promoter and enhancer enrichment in schizophrenia variants associated with expression quantitative trait loci (eQTL). The enrichment is greater when functional annotations derived from the human brain are used relative to peripheral tissues. Regulatory trait concordance analysis ranked genes within schizophrenia genome-wide significant loci for a potential functional role, based on colocalization of a risk SNP, eQTL, and regulatory element sequence. We identified potential physical interactions of noncontiguous proximal and distal regulatory elements. This was verified in prefrontal cortex and -induced pluripotent stem cell-derived neurons for the L-type calcium channel (CACNA1C) risk locus. Our findings point to a functional link between schizophrenia-associated noncoding SNPs and 3D genome architecture associated with chromosomal loopings and transcriptional regulation in the brain
Factor copula models for item response data
Factor or conditional independence models based on copulas are proposed for multivariate discrete data such as item responses. The factor copula models have interpretations of latent maxima/minima (in comparison with latent means) and can lead to more probability in the joint upper or lower tail compared with factor models based on the discretized multivariate normal distribution (or multidimensional normal ogive model). Details on maximum likelihood estimation of parameters for the factor copula model are given, as well as analysis of the behavior of the log-likelihood. Our general methodology is illustrated with several item response data sets, and it is shown that there is a substantial improvement on existing models both conceptually and in fit to data
Modeling Cell Gradient Sensing and Migration in Competing Chemoattractant Fields
Directed cell migration mediates physiological and pathological processes. In particular, immune cell trafficking in tissues is crucial for inducing immune responses and is coordinated by multiple environmental cues such as chemoattractant gradients. Although the chemotaxis mechanism has been extensively studied, how cells integrate multiple chemotactic signals for effective trafficking and positioning in tissues is not clearly defined. Results from previous neutrophil chemotaxis experiments and modeling studies suggested that ligand-induced homologous receptor desensitization may provide an important mechanism for cell migration in competing chemoattractant gradients. However, the previous mathematical model is oversimplified to cell gradient sensing in one-dimensional (1-D) environment. To better understand the receptor desensitization mechanism for chemotactic navigation, we further developed the model to test the role of homologous receptor desensitization in regulating both cell gradient sensing and migration in different configurations of chemoattractant fields in two-dimension (2-D). Our results show that cells expressing normal desensitizable receptors preferentially orient and migrate toward the distant gradient in the presence of a second local competing gradient, which are consistent with the experimentally observed preferential migration of cells toward the distant attractant source and confirm the requirement of receptor desensitization for such migratory behaviors. Furthermore, our results are in qualitative agreement with the experimentally observed cell migration patterns in different configurations of competing chemoattractant fields
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